NDAINJECTIONINJECTABLE
Approved
May 2003
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DUOCAINE (bupivacaine hydrochloride; lidocaine hydrochloride) by R-Pharm US is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Approved for regional anesthesia, analgesia for surgery, dental and 4 more indications. First approved in 2003.
Drug data last refreshed 1h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DUOCAINE is a fixed-dose combination injectable local anesthetic containing bupivacaine hydrochloride and lidocaine hydrochloride. It works by blocking nerve impulse generation and conduction, increasing electrical excitation threshold and slowing action potential propagation. The product is indicated for regional anesthesia, surgical analgesia, dental procedures, and obstetrical use.
LOE Approaching
Product faces imminent loss of exclusivity with high competitive pressure (30/100); brand team likely prioritizes market defense and generic transition planning.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications (7)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.