NDATOPICALGEL
Approved
Aug 2002
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
8
Data completeness
3/8 — Basic
DUAC (benzoyl peroxide; clindamycin phosphate) by GSK is protein. First approved in 2002.
Drug data last refreshed 4h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DUAC is a fixed-dose combination topical gel containing benzoyl peroxide and clindamycin phosphate approved for acne treatment. Benzoyl peroxide acts as an oxidizing agent with bactericidal and keratolytic properties, while clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis. Together, they target both inflammatory and comedonal acne through dual mechanisms.
LOE Approaching
Product is in late-stage lifecycle with moderate competitive pressure (30/100), signaling resource prioritization shift toward LOE mitigation and generic defense rather than growth initiatives.
Mechanism of Action
protein. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (8)
DUAC® Early Onset Efficacy Study in Japanese Subjects
Started Oct 2015
350 enrolled
Acne Vulgaris
A Efficacy and Safety of Duac™Compared With Clindamycin Phosphate Gel in the Treatment of Mild to Moderate Acne Vulgaris
Started Apr 2013
1,018 enrolled
Acne Vulgaris
A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne
Started Aug 2010
286 enrolled
Acne Vulgaris
A Phase 4, Single-Blind, Randomized, Study to Compare the Tolerability and Efficacy of 0.1% Tazorac Cream When Used in Combination With Either Duac Gel or Acanya Gel for the Treatment of Facial Acne Vulgaris
Started Oct 2009
40 enrolled
Acne Vulgaris
Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris
Started Sep 2008
382 enrolled
Acne Vulgaris
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.