DOPTELET SPRINKLE
LOE Approachingavatrombopag
NDAORALGRANULE
Approved
Jul 2025
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
9
Data completeness
5/8 — Partial
DOPTELET SPRINKLE (avatrombopag) is bioavailable, small molecule tpo receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets. First approved in 2025.
Drug data last refreshed 4d ago
Mechanism of Action
bioavailable, small molecule TPO receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets. Avatrombopag does not compete with TPO for binding to the TPO receptor and has an additive…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (9)
Efficacy and Safety of Avatrombopag vs. Avatrombopag Combined With rhTPO in the Treatment of SAA
Started Feb 2024
60 enrolled
Anemia, Aplastic
Avatrombopag vs. Placebo for CIT in GI Malignancies
Started Nov 2023
60 enrolled
Gastrointestinal CancerGastrointestinal NeoplasmsChemotherapy-Induced Thrombocytopenia
Efficacy and Safety of Avatrombopag in Cancer Patients With Thrombocytopenia
Started Jun 2021
30 enrolled
ThrombocytopeniaAvatrombopag
Avatrombopag Usage in NSAA
Started Feb 2021
40 enrolled
Aplastic AnemiaDrug Effect
Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects
Started Apr 2016
48 enrolled
Healthy Participants
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.