NDAINJECTIONINJECTABLE
Approved
May 1981
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
DOPAMINE HYDROCHLORIDE (dopamine hydrochloride) by Pfizer is 3,4 dihydroxyphenylalanine (dopa). Approved for hemodynamic status in patients in shock. First approved in 1981.
Drug data last refreshed 10h ago · AI intelligence enriched 17h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Dopamine hydrochloride is a catecholamine injectable used to manage hemodynamic status in patients in shock by activating dopamine D1 and D2 receptors as well as beta-1 and alpha-1 adrenergic receptors. Its effects are dose-dependent, ranging from renal vasodilation at low doses to increased cardiac contractility at intermediate doses. The drug acts as a precursor to norepinephrine and functions as a neurotransmitter in the central and peripheral nervous systems.
LOE Approaching
This Pfizer-sponsored product is approaching loss of exclusivity with moderate competitive pressure (30), suggesting declining brand team headcount and transition to generic defense strategies.
Mechanism of Action
3,4 dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine elicits its pharmacological…
Indications (1)
Career Relevance
This dopamine HCl role offers limited career growth due to the product's mature, generic-saturated lifecycle and lack of ongoing clinical development. Opportunities are concentrated in defensive commercial strategies, hospital channel management, and supply chain roles rather than innovation-focused positions.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.