NDAINJECTIONINJECTABLE
Approved
May 1981
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DOPAMINE HYDROCHLORIDE (dopamine hydrochloride) by Medica Corp is clinical pharmacology dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (dopa). Approved for hemodynamic status in patients in shock. First approved in 1981.
Drug data last refreshed Yesterday · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Dopamine hydrochloride is a natural catecholamine that acts as a precursor to norepinephrine and a neurotransmitter in the central and peripheral nervous systems. It is indicated for improving hemodynamic status in patients in shock through dose-dependent activation of dopamine, beta-1, and alpha-1 adrenoceptors. The drug produces rapid onset (within 5 minutes) with a short plasma half-life of approximately 2 minutes, making it suitable for acute critical care settings.
LOE Approaching
This is a mature, generic critical care agent approaching loss of exclusivity with moderate competitive pressure (30%), signaling consolidation of brand teams around differentiated delivery formats.
Mechanism of Action
CLINICAL PHARMACOLOGY Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.