NDAORALSUSPENSION
Approved
Oct 1961
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
6/8 — Strong
DIURIL (chlorothiazide) by Bausch Health is clinical pharmacology the mechanism of the antihypertensive effect of thiazides is unknown. Approved for hypertension. First approved in 1961.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIURIL (chlorothiazide) is an oral thiazide diuretic approved in 1961 that lowers blood pressure by increasing sodium and chloride excretion in the distal renal tubules. It is indicated for hypertension, Type 2 diabetes, metabolic syndrome, and abdominal obesity. The drug works through an unknown antihypertensive mechanism but reliably produces diuresis within 2 hours with effects lasting 6-12 hours.
$18KPart D
LOE ApproachingDeclining
Minimal commercial investment expected as product approaches loss of exclusivity with extremely limited Part D utilization of only 233 claims in 2023.
Mechanism of Action
CLINICAL PHARMACOLOGY The mechanism of the antihypertensive effect of thiazides is unknown. DIURIL does not usually affect normal blood pressure. DIURIL affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are approximately equal in…
Pharmacologic Class:
Thiazide Diuretic
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.