NDAORALTABLETPriority Review
Approved
Sep 1958
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
Priority Review
DIURIL (chlorothiazide) by Teva is clinical pharmacology the mechanism of the antihypertensive effect of thiazides is unknown. Approved for hypertension, essential hypertension. First approved in 1958.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIURIL (chlorothiazide) is an oral thiazide diuretic approved in 1958 that reduces blood pressure by increasing sodium and chloride excretion in the distal renal tubule. It treats hypertension and is indicated across multiple cardiometabolic conditions including diabetes, chronic kidney disease, and coronary artery disease. The mechanism of antihypertensive action remains incompletely understood, though diuresis begins within 2 hours and peaks at 4 hours with a 6-12 hour duration.
$18KPart D
LOE ApproachingDeclining
Minimal commercial momentum; small Part D footprint (233 claims in 2023) indicates generic commoditization and reduced brand team support.
Mechanism of Action
CLINICAL PHARMACOLOGY The mechanism of the antihypertensive effect of thiazides is unknown. DIURIL does not usually affect normal blood pressure. DIURIL affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are approximately equal in…
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.