NDAORALTABLETPriority Review
Approved
Sep 1958
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
Priority Review
DIURIL (chlorothiazide) by Teva is clinical pharmacology the mechanism of the antihypertensive effect of thiazides is unknown. First approved in 1958.
Drug data last refreshed 2h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIURIL (chlorothiazide) is a thiazide diuretic approved in 1958 that reduces blood pressure by increasing sodium and chloride excretion in the distal renal tubule. It is used to manage hypertension and edema, with diuresis beginning within 2 hours and lasting 6-12 hours. The exact mechanism of antihypertensive effect remains unknown, though renal tubular effects are well-characterized.
$0.018BPart D
LOE ApproachingMinimal commercial opportunity with only 233 Part D claims in 2023 and LOE approaching; brand team likely minimal or consolidating.
Mechanism of Action
CLINICAL PHARMACOLOGY The mechanism of the antihypertensive effect of thiazides is unknown. DIURIL does not usually affect normal blood pressure. DIURIL affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are approximately equal in…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
A Study to Learn How the Body Processes Spironolactone and Hydrochlorothiazide Film Coated Tablets Manufactured at Two Sites: Viatris and Neolpharma
Started Dec 2023
42 enrolled
Healthy Participants
Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice
Started Jun 2022
0Hypertension
Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.
Started Sep 2018
0HypertensionDiabetes Mellitus, Type 2
A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide
Started Jan 2018
16 enrolled
Type 2 Diabetes Mellitus
Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions
Started Mar 2017
42 enrolled
Hypertension
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.