DITROPAN
LOE ApproachingNDAORALTABLET
Approved
Jul 1975
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DITROPAN by Johnson & Johnson is clinical pharmacology oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Approved for overactive bladder with symptoms of urge urinary incontinence, urgency, frequency and 2 more indications. First approved in 1975.
Drug data last refreshed 3d ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DITROPAN (oxybutynin chloride) is an oral anticholinergic agent approved in 1975 that exerts direct antispasmodic effects on bladder smooth muscle by inhibiting muscarinic acetylcholine action. It is indicated for overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency in adults, and for pediatric patients aged 6+ with detrusor overactivity associated with neurological conditions.
LOE Approaching
As a mature product approaching loss of exclusivity, DITROPAN brand team faces transition planning and potential rightsizing; focus likely shifting toward generic defense or portfolio redeployment.
Mechanism of Action
CLINICAL PHARMACOLOGY Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.