NDATOPICALOINTMENT, AUGMENTED
Approved
Jul 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
19
Data completeness
5/8 — Partial
DIPROLENE (betamethasone dipropionate) by Merck & Co. is signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of diprolene ointment in corticosteroid responsive dermatoses is unknown. First approved in 1983.
Drug data last refreshed 5h ago · AI intelligence enriched 8h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIPROLENE is an augmented topical ointment formulation of betamethasone dipropionate, a potent corticosteroid approved by FDA in 1983. It suppresses immune function and reduces inflammation through modulation of signaling and protein regulation, though its precise mechanism in corticosteroid-responsive dermatoses remains incompletely understood. The product is used to treat inflammatory skin conditions in patients requiring topical corticosteroid therapy.
$0.012BPart D
LOE ApproachingProduct is approaching loss of exclusivity with modest Part D utilization, signaling potential downsizing of brand team resources and shift toward generic defense strategies.
Mechanism of Action
signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of DIPROLENE Ointment in corticosteroid responsive dermatoses is unknown.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (19)
The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS)
Started Aug 2023
24 enrolled
Chronic Rhinosinusitis (Diagnosis)
A Study to Assess Treatment Satisfaction, Patient-reported Outcomes, Effectiveness, and Safety of a Fixed-dose Combination of Calcipotriene/Betamethasone Dipropionate PAD Cream in the Treatment of Mild-to-moderate Plaque Psoriasis of the Scalp in Adults
Started Jun 2023
291 enrolled
Plaque Psoriasis
Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream
Started Feb 2022
2 enrolled
Chronic Rhinosinusitis (Diagnosis)
Clinical Trial to Assess Safety, Tolerability and the Pharmacodynamics Effect of Calcipotriol/Betamethasone Dipropionate in a New Administration Form in Subjects With Chronic Plaque Psoriasis.
Started Apr 2019
15 enrolled
Psoriasis Vulgaris
Skin Irritation of LEO 90100 Foam (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese Subjects
Started Jan 2018
20 enrolled
Psoriasis Vulgaris
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.