NDAINJECTIONINJECTABLE
Approved
Oct 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
DIPRIVAN (propofol) by Fresenius Kabi is action, like all general anesthetics, is poorly understood. Approved for general anesthetic [epc]. First approved in 1989.
Drug data last refreshed 9h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIPRIVAN (propofol) is a short-acting general anesthetic administered intravenously for induction and maintenance of anesthesia. It works by positive modulation of GABA A receptors to produce sedative and anesthetic effects, though the precise mechanism remains incompletely understood. Used across inpatient surgical, ICU sedation, and procedural settings, propofol remains a cornerstone agent in anesthesia practice.
LOE Approaching
As an established injectable approaching loss of exclusivity with moderate competitive pressure (30/100), brand teams face declining market opportunity requiring efficiency and transition planning.
Mechanism of Action
action, like all general anesthetics, is poorly understood. However, propofol is thought to produce its sedative/anesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABA A receptors.
Pharmacologic Class:
General Anesthetic
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Propofol or Esketamine: Tracheal Intubation Comparison
Started Oct 2026
130 enrolled
Critically Ill Adults Requiring Emergency Tracheal Intubation in the Intensive Care Unit
Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients
Started Sep 2026
381 enrolled
Brain NeoplasmsDelirium - Postoperative
Propofol Dose-Finding for Colonoscope Insertion in Geriatric Patients
Started Sep 2025
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
Started Jun 2023
60 enrolled
Critical Illness
Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery
Started May 2023
252 enrolled
Pituitary Adenoma
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.