NDAINJECTIONINJECTABLE
Approved
Oct 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
DIPRIVAN (propofol) by Fresenius Kabi is action, like all general anesthetics, is poorly understood. Approved for general anesthetic [epc]. First approved in 1989.
Drug data last refreshed 2d ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIPRIVAN (propofol) is a general anesthetic administered by injection for induction and maintenance of anesthesia in surgical and critical care settings. It works by positive modulation of inhibitory GABA-A receptors in the central nervous system, though its precise mechanism remains incompletely understood. Propofol is a cornerstone agent in perioperative medicine and ICU sedation.
LOE Approaching
As LOE approaches, the brand team is likely consolidating to protect market share against generics in a mature, competitive anesthetic market.
Mechanism of Action
action, like all general anesthetics, is poorly understood. However, propofol is thought to produce its sedative/anesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABA A receptors.
Pharmacologic Class:
General Anesthetic
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Propofol Dose-Finding for Colonoscope Insertion in Geriatric Patients
Started Sep 2025
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
Started Jun 2023
60 enrolled
Critical Illness
Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery
Started May 2023
252 enrolled
Pituitary Adenoma
Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery
Started Nov 2022
1,317 enrolled
Emergence AgitationRemimazolam BesylatePerioperative Sedation+2 more
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
Started Sep 2022
60 enrolled
Critically IllDeep Sedation
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.