DIMETANE-DX
LOE Approachingbrompheniramine maleate; dextromethorphan hydrobromide; pseudoephedrine hydrochloride
NDAORALSYRUP
Approved
Aug 1984
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DIMETANE-DX (brompheniramine maleate; dextromethorphan hydrobromide; pseudoephedrine hydrochloride) is clinical pharmacology brompheniramine maleate is a histamine antagonist, specifically an h 1 -receptor-blocking agent belonging to the alkylamine class of antihistamines. Approved for nasal congestion due to the common cold, hay fever, other upper respiratory allergies temporarily relieves these symptoms due to hay fever (allergic rhinitis) runny nose itchy and 2 more indications. First approved in 1984.
Drug data last refreshed 13h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIMETANE-DX is a triple-combination oral syrup containing brompheniramine maleate (H1-receptor antagonist), dextromethorphan hydrobromide (antitussive), and pseudoephedrine hydrochloride (nasal decongestant). It treats nasal congestion, cough, and allergic symptoms associated with the common cold, hay fever, and upper respiratory allergies. The combination works through antihistamine, cough-suppression, and sympathomimetic mechanisms to address multiple cold and allergy symptoms simultaneously.
LOE Approaching
Product is in late-stage lifecycle with moderate competitive pressure (30), signaling focus on market defense and potential transition planning rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Brompheniramine maleate is a histamine antagonist, specifically an H 1 -receptor-blocking agent belonging to the alkylamine class of antihistamines. Antihistamines appear to compete with histamine for receptor sites on effector cells. Brompheniramine also has anticholinergic…
Indications (5)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
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