DIMETANE-DX
LOE Approachingbrompheniramine maleate; dextromethorphan hydrobromide; pseudoephedrine hydrochloride
NDAORALSYRUP
Approved
Aug 1984
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DIMETANE-DX (brompheniramine maleate; dextromethorphan hydrobromide; pseudoephedrine hydrochloride) is clinical pharmacology brompheniramine maleate is a histamine antagonist, specifically an h 1 -receptor-blocking agent belonging to the alkylamine class of antihistamines. Approved for nasal congestion due to the common cold, hay fever, other upper respiratory allergies temporarily relieves these symptoms due to hay fever (allergic rhinitis) runny nose itchy and 2 more indications. First approved in 1984.
Drug data last refreshed 11h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIMETANE-DX is a fixed-dose combination oral syrup containing brompheniramine maleate (H1-receptor antagonist), dextromethorphan hydrobromide (antitussive), and pseudoephedrine hydrochloride (nasal decongestant). It treats upper respiratory allergy and cold symptoms including nasal congestion, runny nose, sneezing, cough, and watery eyes. The triple mechanism addresses allergic response suppression, cough suppression, and nasal vasoconstriction simultaneously.
LOE Approaching
As LOE approaches, the brand team is likely in transition mode with focus shifting from growth maintenance to pipeline continuity and managed decline strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY Brompheniramine maleate is a histamine antagonist, specifically an H 1 -receptor-blocking agent belonging to the alkylamine class of antihistamines. Antihistamines appear to compete with histamine for receptor sites on effector cells. Brompheniramine also has anticholinergic…
Indications (5)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
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