DILATRATE-SR
LOE Approachingisosorbide dinitrate
NDAORALCAPSULE, EXTENDED RELEASE
Approved
Sep 1988
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
Clinical Pharmacology The principal pharmacological action of isosorbide dinitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to…