NDAORALFOR SUSPENSION
Approved
Dec 1993
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
DIFLUCAN (fluconazole) by Pfizer is cytochrome p450 2c19 inhibitors [moa]. First approved in 1993.
Drug data last refreshed 11h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIFLUCAN (fluconazole) is an oral azole antifungal agent that works by inhibiting fungal cytochrome P450 2C19, disrupting ergosterol synthesis in fungal cell membranes. Approved in 1993, it is used to treat various fungal infections across multiple body systems. The drug has become a standard-of-care option for candidiasis and other fungal infections in both immunocompromised and immunocompetent patients.
$0.229MPart D
LOE ApproachingDeclining
As LOE approaches with minimal Part D spending, the brand team is likely contracting; career opportunities focus on generic transition management and niche positioning rather than growth expansion.
Mechanism of Action
Cytochrome P450 2C19 Inhibitors
Pharmacologic Class:
Azole Antifungal
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
A Study of Fluconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems
100 enrolled
Candidiasis, EsophagealHIV Infections
A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS
Meningitis, CryptococcalHIV Infections
Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS
330 enrolled
Meningitis, CryptococcalHIV Infections
A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis
Meningitis, CryptococcalHIV Infections
A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
Meningitis, CryptococcalHIV Infections
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.