NDAORALTABLET
Approved
Oct 1960
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
DIDREX (benzphetamine hydrochloride) by Pfizer is clinical pharmacology benzphetamine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Approved for the management of exogenous obesity, higher. First approved in 1960.
Drug data last refreshed 7h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DIDREX (benzphetamine hydrochloride) is a sympathomimetic amine oral tablet approved in 1960 for management of exogenous obesity. It works through central nervous system stimulation and blood pressure elevation to suppress appetite, though the exact mechanism beyond appetite suppression remains unclear. Clinical studies show modest weight loss benefit (a fraction of a pound per week above placebo) with tolerance developing over time.
LOE Approaching
Product approaching loss of exclusivity with minimal remaining commercial potential; career opportunities shrinking as team consolidates toward lifecycle management.
Mechanism of Action
CLINICAL PHARMACOLOGY Benzphetamine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance…
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.