DIABETA

LOE Approaching

glyburide

NDAORALTABLET
Approved
May 1984
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
18

Mechanism of Action

CLINICAL PHARMACOLOGY Glyburide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which Glyburide lowers blood glucose during long-term administration has not…

Pharmacologic Class:

Sulfonylurea

Clinical Trials (5)

NCT03856970Phase 1Completed

Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers

Started Mar 2019
87 enrolled
Healthy Volunteers
NCT01716338Phase 1Completed

Glyburide Healthy Volunteer Study

Started Jan 2013
21 enrolled
Healthy Volunteers
NCT01132703Phase 1Completed

Safety Study of RP-1127 (Glyburide for Injection) in Healthy Volunteers

Started Jan 2010
34 enrolled
Traumatic Brain InjuryStroke
NCT01733108Phase 1Completed

A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Glyburide in Healthy Volunteers

Started Jul 2008
29 enrolled
Healthy
NCT02183428Phase 1Completed

Bioavailability of BI 1356 and Glyburide in Healthy Male and Female Volunteers

Started May 2008
20 enrolled
Healthy