NDAINJECTIONINJECTABLEPriority Review
Approved
Oct 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
9
Data completeness
6/8 — Strong
Priority Review
DEPO-PROVERA (medroxyprogesterone acetate) by Pfizer is suspension, usp inhibits the secretion of gonadotropins which primarily prevents follicular maturation and ovulation and causes thickening of cervical mucus. Approved for contraception, endometriosis, menorrhagia. First approved in 1992.
Drug data last refreshed 23h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DEPO-PROVERA (medroxyprogesterone acetate) is a long-acting injectable progestin that inhibits gonadotropin secretion to prevent ovulation and thicken cervical mucus, primarily used for contraception. The product is indicated across a broad range of conditions including contraception, endometriosis, menorrhagia, endometrial hyperplasia, and hormone-responsive cancers. It represents a foundational hormonal therapy with decades of clinical use and established safety profile.
$10KPart D
LOE ApproachingDeclining
Mature product nearing loss of exclusivity with minimal Medicare claims, indicating small team size and reduced investment focus compared to peak-cycle competitors.
Mechanism of Action
Suspension, USP inhibits the secretion of gonadotropins which primarily prevents follicular maturation and ovulation and causes thickening of cervical mucus. These actions contribute to its contraceptive effect.
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.