DELSYM

LOE Approaching

dextromethorphan

NDAORALSUSPENSION, EXTENDED RELEASE
Approved
Oct 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
17

Mechanism of Action

Uncompetitive NMDA Receptor Antagonists

Pharmacologic Class:

Uncompetitive N-methyl-D-aspartate Receptor Antagonist

Clinical Trials (5)

NCT07241065Phase 1Not Yet Recruiting

A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy Participants

Started Jan 2026
35 enrolled
Healthy Participants
NCT05236530Phase 1Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir

Started Mar 2022
48 enrolled
Malaria
NCT03393520Phase 3Completed

Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

Started Oct 2017
601 enrolled
Agitation in Patients With Dementia of the Alzheimer's Type
NCT02651116Phase 4Terminated

Dextromethorphan Pediatric Acute Cough Study

Started Feb 2016
131 enrolled
Cough
NCT02246166Phase 4Completed

The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza.

Started Jan 2015
53 enrolled
Common Cold