NDAINTRAVENOUSSOLUTIONPriority Review
Approved
Mar 2016
Lifecycle
Peak
Competitive Pressure
0/100
Mechanism of Action
elucidated. In vitro , defibrotide sodium enhances the enzymatic activity of plasmin to hydrolyze fibrin clots. Studies evaluating the pharmacological effects of defibrotide sodium on endothelial cells (ECs) were conducted primarily in the human microvascular endothelial cell line. In vitro ,…
Loss of Exclusivity
LOE Date
Jun 22, 2032
76 months away
Patent Expiry
Jun 22, 2032