DECLOMYCIN
LOE Approachingdemeclocycline hydrochloride
NDAORALTABLET
Approved
Sep 1964
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
CLINICAL PHARMACOLOGY Pharmacokinetics The absorption of demeclocycline is slower than that of tetracycline. The time to reach the peak concentration is about 4 hours. After a 150 mg oral dose of demeclocycline tablet, the mean concentrations at 1 hour and 3 hours are 0.46 and 1.22 mcg/mL (n = 6),…
Indications (10)
infections caused by the following gram-negative microorganismsbacteriologic testing indicates appropriate susceptibility to the drug: Escherichia coliinfections caused by the following gram-positive microorganismsbacteriologic testing indicates appropriate susceptibility to the drug: Upper respiratory infections caused by Streptococcus pneumoniaethe treatment of infections caused by susceptible strains of the designated microorganisms in the conditions below: Rocky Mountain spotted fevertyphus feverthe typhus groupQ feverrickettsialpoxtick fevers caused by rickettsiae