DARVON-N
LOE Approachingpropoxyphene napsylate
NDAORALSUSPENSION
Approved
Sep 1971
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
CLINICAL PHARMACOLOGY Pharmacology Propoxyphene is a centrally acting opiate analgesic. In vitro studies demonstrated propoxyphene and the metabolite norpropoxyphene inhibit sodium channels (local anesthetic effect) with norpropoxyphene being approximately 2-fold more potent than propoxyphene and…