DARAPRIM
LOE Approachingpyrimethamine
NDAORALTABLETPriority Review
Approved
Jan 1953
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
7
Mechanism of Action
Dihydrofolate Reductase Inhibitors
Pharmacologic Class:
Dihydrofolate Reductase Inhibitor Antimalarial
Indications (2)
Clinical Trials (5)
Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects
Started Sep 2017
14 enrolled
Toxoplasmosis
Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa
Started Oct 2010
2,891 enrolled
Intermittent Preventive Treatment In Pregnancy (IPTp)
Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine For The Treatment Of Uncomplicated, Symptomatic Falciparum Malaria In Southeast Asia
Started Mar 2004
32 enrolled
Malaria, Falciparum
Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India
Started Sep 2003
230 enrolled
PLASMODIUM FALCIPARUM MALARIA
ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan
Started Jun 2001
650 enrolled
MalariaFalciparum MalariaVivax Malaria