NDAINJECTIONINJECTABLE
Approved
Apr 1946
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action Dihydroergotamine binds with high affinity to 5-HT 1Dα and 5-HT 1Dβ receptors. It also binds with high affinity to serotonin 5-HT 1A, 5-HT 2A, and 5-HT 2C receptors, noradrenaline α 2A, α 2B and α 1 receptors, and dopamine D 2L and D 3 receptors. The…
Indications (1)
Clinical Trials (1)
Pharmacodynamic Study to Compare Acute Effects of Dihydroergotamine Mesylate (DHE) on Pulmonary Arterial Pressure
Started Mar 2010
24 enrolled
Healthy