CYMBALTA
LOE ApproachingNDAORALCAPSULE, DELAYED REL PELLETS
Approved
Jun 2008
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
5
Data completeness
4/8 — Partial
CYMBALTA by Eli Lilly and Company is antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the cns. Approved for the following conditions: major depressive disorder (mdd) in adults () generalized anxiety disorder (gad) in adults, older () diabetic peripheral neuropathic pain (dpnp) in adults () fibromyalgia (fm) in adults, older () chronic musculoskeletal pain in adults (). First approved in 2008.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CYMBALTA (duloxetine) is an oral serotonin-norepinephrine reuptake inhibitor (SNRI) approved in 2008 for depression, dysthymic disorder, and chronic pain conditions. It works by potentiating serotonergic and noradrenergic activity in the central nervous system to produce antidepressant, anxiolytic, and pain-inhibitory effects.
LOE Approaching
Product faces patent expiration and generic competition pressure; brand teams are likely consolidating and shifting focus to value maintenance and portfolio optimization.
Mechanism of Action
antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.