NDAORALTABLET
Approved
Dec 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
CYKLOKAPRON (tranexamic acid) by Pfizer is derivative, which diminishes the dissolution of hemostatic fibrin by plasmin. First approved in 1986.
Drug data last refreshed 25m ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Cyklokapron is an oral antifibrinolytic agent containing tranexamic acid that stabilizes fibrin clots by blocking plasmin-mediated fibrin dissolution. It works by occupying high-affinity lysine binding sites on plasminogen, preventing plasminogen attachment to fibrin and preserving clot structure. The drug is used to reduce excessive bleeding in patients at hemostatic risk.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30%), suggesting defensive strategy and potential team contraction in coming years.
Mechanism of Action
derivative, which diminishes the dissolution of hemostatic fibrin by plasmin. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin's matrix structure. The…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma
Started May 2026
120 enrolled
Melasma
Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial
Started Nov 2025
1,546 enrolled
Liver TransplantationTranexamic AcidEnd-stage Liver Disease (ESLD)
Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery
Started Jun 2024
850 enrolled
Surgical Blood LossTransfusion-dependent AnemiaAbdomen Disease
Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects
Started Jan 2024
65 enrolled
BleedingContraceptive Device; Complications
Tranexamic Acid to Reduce Blood Loss in Women Having Planned Cesarean Section
Started Nov 2023
68 enrolled
Cesarean SectionBlood Loss During Surgery
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.