NDAINJECTIONINJECTABLEPriority Review
Approved
Dec 2006
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
Priority Review
CYANOKIT (hydroxocobalamin) by Teva is poison. Approved for known, suspected cyanide poisoning. First approved in 2006.
Drug data last refreshed 8h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CYANOKIT (hydroxocobalamin) is an antidote for acute cyanide poisoning approved in 2006. It works by binding cyanide ions and converting them to cyanocobalamin, which is then excreted in urine, restoring cellular respiration. This is a life-saving emergency medicine with rapid onset of action.
LOE Approaching
Product is approaching loss of exclusivity with modest competitive pressure (30); small team focus likely shifting toward generic transition and hospital inventory management.
Mechanism of Action
poison. In the absence of rapid and adequate treatment, exposure to a high dose of cyanide can result in death within minutes due to the inhibition of cytochrome oxidase resulting in arrest of cellular respiration. Specifically, cyanide binds rapidly with cytochrome a3, a component of the…
Pharmacologic Class:
Antidote
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.