NDAORALCAPSULE
Approved
Dec 1970
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
6/8 — Strong
CUPRIMINE (penicillamine) by Bausch + Lomb is clinical pharmacology penicillamine is a chelating agent recommended for the removal of excess copper in patients with wilson's disease. Approved for wilson disease. First approved in 1970.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CUPRIMINE (penicillamine) is an oral chelating agent and antirheumatic drug approved in 1970 for Wilson disease, cystinuria, and rheumatoid arthritis. It works by binding excess copper and cystine, reducing their excretion, and suppressing rheumatoid disease activity through T-cell depression and rheumatoid factor reduction. The mechanism in rheumatoid arthritis remains incompletely understood but produces clinical responses within 2-3 months in responders.
$0.002BPart D
LOE ApproachingProduct is approaching loss of exclusivity with minimal Part D presence ($2M, 64 claims in 2023), indicating a niche-market mature asset with limited commercial expansion opportunity.
Mechanism of Action
CLINICAL PHARMACOLOGY Penicillamine is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine, it would appear that 1 g of penicillamine should be…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.