CRIXIVAN
LOE ApproachingNDAORALCAPSULEPriority Review
Approved
Mar 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
Priority Review
CRIXIVAN by Merck & Co. is mechanism of action: hiv-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious hiv-1. Approved for hiv infection. First approved in 1996.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CRIXIVAN (indinavir) is an oral HIV-1 protease inhibitor approved in 1996 that binds to the HIV protease active site and prevents viral polyprotein cleavage, resulting in non-infectious immature viral particles. It is used as part of combination antiretroviral therapy for HIV infection. The drug represents a foundational protease inhibitor class that transformed HIV treatment in the mid-1990s.
LOE Approaching
As a mature protease inhibitor approaching loss of exclusivity with moderate competitive pressure, the brand team is likely small and focused on managed decline and niche patient populations.
Mechanism of Action
Mechanism of Action: HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents…
Indications (1)
Clinical Trials (1)
A Comparison of Epivir Plus Crixivan Combined With Zerit or Retrovir in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
200 enrolled
HIV Infections
Career Relevance
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.