COUMADIN

LOE Approaching

warfarin sodium

NDAORALTABLET
Approved
Jun 1954
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2

Mechanism of Action

K-dependent clotting factors, which include Factors II, VII, IX, and X, and the anticoagulant proteins C and S. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K-dependent clotting factors. Vitamin K promotes the biosynthesis of γ-carboxyglutamic acid residues in…

Clinical Trials (2)

NCT00928915Phase 4Completed

International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage

Started Jul 2009
54 enrolled
Intracranial Hemorrhages
NCT02171494Phase 1Completed

Bioequivalence of IVAX Warfarin Tablets and Coumadin Brand Warfarin Tablets in Healthy Volunteers

Started Sep 2008
36 enrolled
Healthy