COSELA

PeakSM

trilaciclib

NDAINTRAVENOUSPOWDERPriority Review
Approved
Feb 2021
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
2

Mechanism of Action

4 and 6. Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow give rise to circulating neutrophils, RBCs, and platelets. HSPC proliferation is dependent on CDK4/6 activity.

Clinical Trials (2)

NCT06027268Phase 2Active Not Recruiting

Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast Cancer

Started Jan 2024
36 enrolled
Metastatic Triple-Negative Breast Cancer
NCT03041311Phase 2Completed

Carboplatin, Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28), a CDK4/6 Inhibitor, in Extensive-Stage SCLC

Started Jun 2017
107 enrolled
Small Cell Lung Cancer

Loss of Exclusivity

LOE Date
Nov 13, 2040
178 months away
Patent Expiry
Nov 13, 2040
Exclusivity Expiry
Feb 12, 2026

Patent Records (5)

Patent #ExpiryTypeUse Code
9957276
Oct 25, 2031
Substance
10189850
Oct 25, 2031
Product
8598197
Oct 25, 2031
SubstanceProduct
10927120
Oct 25, 2031
Product
10189849
Oct 25, 2031
Substance