NDAORALTABLET
Approved
May 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CORZIDE (bendroflumethiazide; nadolol) by Pfizer is clinical pharmacology nadolol nadolol is a nonselective beta-adrenergic receptor blocking agent. Approved for hypertension, to lower blood pressure, heart failure. First approved in 1983.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CORZIDE is a fixed-dose combination of nadolol (a nonselective beta-blocker) and bendroflumethiazide (a thiazide diuretic) for oral use. It treats hypertension and heart failure by reducing heart rate, cardiac output, and blood pressure through dual mechanisms: beta-adrenergic receptor blockade and diuresis. The combination leverages nadolol's low lipophilicity and CNS penetration, making it suitable for long-term cardiovascular management.
LOE Approaching
As LOE approaches, the product is in managed decline with reduced investment in brand expansion; teams typically scale down in size and shift toward generic transition planning and patient retention initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Nadolol Nadolol is a nonselective beta-adrenergic receptor blocking agent. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.