CORTISPORIN
LOE Approachingbacitracin zinc; hydrocortisone; neomycin sulfate; polymyxin b sulfate
NDAOPHTHALMICOINTMENT
Approved
May 1971
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CORTISPORIN (bacitracin zinc; hydrocortisone; neomycin sulfate; polymyxin b sulfate) by R-Pharm US is clinical pharmacology colistin sulfate is a polypeptide antibiotic which penetrates into and disrupts the bacterial cell membrane. Approved for superficial bacterial infections of the external auditory canal, caused by organisms susceptible to the action of the antibiotics. First approved in 1971.
Drug data last refreshed 21h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CORTISPORIN is a fixed-dose combination ointment containing four active ingredients: bacitracin zinc, hydrocortisone, neomycin sulfate, and polymyxin B sulfate. It treats superficial bacterial infections of the external auditory canal caused by susceptible organisms through dual mechanisms: antibiotics disrupt bacterial cell membranes and protein synthesis, while hydrocortisone reduces inflammation and pruritus. The product combines broad-spectrum bactericidal activity against gram-positive and gram-negative pathogens with anti-inflammatory corticosteroid effects.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30%), likely supporting a smaller, efficiency-focused brand team focused on retention and cost management.
Mechanism of Action
CLINICAL PHARMACOLOGY Colistin sulfate is a polypeptide antibiotic which penetrates into and disrupts the bacterial cell membrane. Neomycin sulfate is an aminoglycoside antibiotic which inhibits protein synthesis, disrupting the normal cycle of ribosomal function. Hydrocortisone acetate is a…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.