COMBIPRES

LOE Approaching

chlorthalidone; clonidine hydrochloride

Boehringer Ingelheim
NDAORALTABLETPriority Review
Approved
Sep 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100

Mechanism of Action

CLINICAL PHARMACOLOGY Chlorthalidone is an oral diuretic with prolonged action (48–72 hours) and low toxicity. The major portion of the drug is excreted unchanged by the kidneys. The diuretic effect of the drug occurs in approximately 2.6 hours and continues for up to 72 hours. The mean half-life…

Indications (9)

the management of hypertension eitherto enhance the effect of other antihypertensive drugs in the more severe forms of hypertensionpregnancyjustbelow)hypertensionheart failuredevelopment of toxemia of pregnancythere is no satisfactory evidence
Company
Boehringer Ingelheim
Boehringer Ingelheim
INGELHEIM, Germany
External Resources
DailyMed
Full prescribing information
FDA Drugs@FDA
FDA approval history
RxNorm
Drug nomenclature & identifiers