NDATRANSDERMALFILM, EXTENDED RELEASE
Approved
Aug 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
COMBIPATCH (estradiol/norethindrone acetate transdermal system) by Noven Pharmaceuticals is estrogen receptor agonists [moa]. Approved for a woman with a uterus for: treatment of moderate to severe vasomotor symptoms due to menopause. First approved in 1998.
Drug data last refreshed 4h ago · AI intelligence enriched 20h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
COMBIPATCH is a transdermal film delivering estradiol and norethindrone acetate for moderate to severe vasomotor symptoms in menopausal women with an intact uterus. It works via estrogen receptor agonism to manage hot flashes and related menopause symptoms. The extended-release formulation provides sustained hormone delivery through the skin.
$5MPart D
LOE ApproachingProduct approaching loss of exclusivity with modest Medicare spending ($5M, 11.5K claims in 2023) and 30% competitive pressure indicates a declining brand team and shift toward generic support roles.
Mechanism of Action
Estrogen Receptor Agonists
Pharmacologic Class:
Estrogen
Career Relevance
Career opportunities on COMBIPATCH are concentrated in manufacturing and quality roles, reflecting the product's mature lifecycle and focus on operational efficiency rather than growth. Positions are technical and production-oriented, with limited commercial or medical affairs expansion.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.