COMBIGAN

LOE Approaching

brimonidine tartrate, timolol maleate

NDAOPHTHALMICSOLUTION/DROPS
Approved
Oct 2007
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
10

Mechanism of Action

components: brimonidine tartrate and timolol. Each of these two components decreases elevated intraocular pressure, whether or not associated with glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher…

Clinical Trials (5)

NCT02863705Phase 4Completed

Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG)

Started Jul 2016
118 enrolled
Glaucoma, Open-AngleNormal Tension Glaucoma
NCT02167035Phase 4Completed

Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)

Started Aug 2014
43 enrolled
GlaucomaOcular Hypertension
NCT01514734Phase 4Terminated

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brimonidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Brazil

Started Mar 2012
9 enrolled
Glaucoma
NCT01518244Phase 4Completed

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Latin America

Started Dec 2011
50 enrolled
Glaucoma
NCT01415401Phase 4Completed

Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada

Started Sep 2011
57 enrolled
GlaucomaOcular HypertensionOpen-angle Glaucoma