NDAOPHTHALMICSOLUTION/DROPS
Approved
Oct 2007
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
12
Data completeness
6/8 — Strong
COMBIGAN (brimonidine tartrate, timolol maleate) by AbbVie is components: brimonidine tartrate and timolol. Approved for elevated intraocular pressure (iop) in patients with glaucoma, ocular hypertension, replacement therapy due to inadequately controlled iop and 2 more indications. First approved in 2007.
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
COMBIGAN is a fixed-dose ophthalmic combination of brimonidine tartrate (alpha-2 adrenergic agonist) and timolol maleate (non-selective beta-blocker) approved in 2007 for reducing elevated intraocular pressure in glaucoma and ocular hypertension. The product works through dual mechanisms: brimonidine decreases aqueous humor production and increases uveoscleral outflow, while timolol inhibits beta-1 and beta-2 adrenergic receptors to further lower IOP. Both components have rapid onset with peak effect within 1-2 hours, making COMBIGAN suitable for patients requiring multi-mechanism IOP control.
$0.2BPart D
Mechanism of Action
components: brimonidine tartrate and timolol. Each of these two components decreases elevated intraocular pressure, whether or not associated with glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.