NDAORALGRANULEPriority Review
Approved
Apr 1977
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
6/8 — Strong
Priority Review
COLESTID (colestipol hydrochloride) by Pfizer is clinical pharmacology cholesterol is the major, and probably the sole precursor of bile acids. Approved for hypertension. First approved in 1977.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
COLESTID (colestipol hydrochloride) is an oral anion exchange resin bile acid sequestrant approved in 1977 for cholesterol management. It binds bile acids in the intestine, preventing their reabsorption and increasing fecal loss, which triggers increased hepatic cholesterol oxidation and LDL receptor upregulation. The mechanism results in decreased serum cholesterol and LDL levels, with effects typically evident within one month.
$199KPart D
LOE ApproachingDeclining
Approaching loss of exclusivity with minimal Medicare utilization signals significant market contraction and likely team resource reduction.
Mechanism of Action
CLINICAL PHARMACOLOGY Cholesterol is the major, and probably the sole precursor of bile acids. During normal digestion, bile acids are secreted via the bile from the liver and gall bladder into the intestines. Bile acids emulsify the fat and lipid materials present in food, thus facilitating…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.