CLOPRA

Pre-Launch

metoclopramide hydrochloride

ANDAORALTABLET
Lifecycle
Pre-Launch
Clinical Trials
4

Mechanism of Action

gastric, biliary, or pancreatic secretions. The exact mechanism of action of metoclopramide in the treatment of gastroesophageal reflux and acute and recurrent diabetic gastroparesis has not been fully established. It seems to sensitize tissues to the action of acetylcholine. The effect of…

Clinical Trials (4)

NCT01953081Phase 1/2Completed

A Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of a Single Dose of Intravenous TD-8954 Compared With Metoclopramide in Critically Ill Patients With Enteral Feeding Intolerance

Started Jan 2014
13 enrolled
Enteral Feeding Intolerance
NCT02098499Phase 4Withdrawn

Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT

Started Jun 2013
0
Migraine HeadachesNauseaRestlessness
NCT01907633N/ACompleted

An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide

Started Dec 2011
15,000 enrolled
Death, Sudden, Cardiac
NCT00139893N/ACompleted

A Randomized, Open-label, Two-way Crossover Trial to Determine the Pharmacokinetics of Metoclopramide When Administered as the Orally Disintegrating Tablet Compared to Reglan® Tablets in Subjects With Diabetic Gastroparesis

Started Jun 2005
Diabetic Gastroparesis