CLONIDINE HYDROCHLORIDE (clonidine hydrochloride) by Hikma is mechanism of action epidurally administered clonidine produces dose-dependent analgesia not antagonized by opiate antagonists. Approved for combination with opiates for the treatment of severe pain in cancer patients. First approved in 2011.
Drug data last refreshed 19h ago
Mechanism of Action Epidurally administered clonidine produces dose-dependent analgesia not antagonized by opiate antagonists. The analgesia is limited to the body regions innervated by the spinal segments where analgesic concentrations of clonidine are present. Clonidine is thought to produce…
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