CLARINEX
LOE ApproachingNDAORALSOLUTION
Approved
Sep 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CLARINEX by Merck & Co. is 1 -receptor histamine antagonist activity. First approved in 2004.
Drug data last refreshed 21h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CLARINEX is an oral antihistamine solution containing desloratadine, a selective H1-receptor antagonist, used to treat allergic rhinitis and urticaria. It works by blocking histamine at the receptor level without significantly crossing the blood-brain barrier, minimizing sedation. The formulation may also contain pseudoephedrine sulfate as a decongestant to address nasal congestion.
$0.289MPart D
LOE ApproachingProduct is approaching loss of exclusivity with minimal Part D penetration (537 claims in 2023), signaling a declining or niche commercial presence and reduced team investment.
Mechanism of Action
1 -receptor histamine antagonist activity. Receptor binding data indicate that at a concentration of 2 to 3 ng/mL (7 nanomolar), desloratadine shows significant interaction with the human histamine H 1 receptor. Desloratadine inhibited histamine release from human mast cells in vitro . Results of a…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on CLARINEX offers limited career progression given its mature lifecycle, minimal job openings, and approaching loss of exclusivity. Roles are primarily defensive and focused on market maintenance rather than growth or innovation.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.