NDAINJECTIONINJECTABLEPriority Review
Approved
Nov 1965
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
Priority Review
CITANEST (prilocaine hydrochloride) by AstraZeneca is mechanism of action prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. First approved in 1965.
Drug data last refreshed 16h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CITANEST (prilocaine hydrochloride) is a local anesthetic administered by injection that stabilizes neuronal membranes to block nerve impulses and pain sensation. It is used for infiltration anesthesia, nerve blocks, and regional anesthesia in surgical and procedural settings. The drug has been a cornerstone of anesthetic practice since 1965 approval.
LOE Approaching
As a mature injectable anesthetic approaching loss of exclusivity with moderate competitive pressure (30%), the brand team is likely focused on defending market share against generics and cost-management strategies rather than growth initiatives.
Mechanism of Action
Mechanism of Action Prilocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
CITANEST offers limited career growth due to zero linked job postings and a mature, LOE-approaching product with stable but declining market dynamics. Roles available are primarily defensive and focused on market access, cost management, and sales force optimization rather than innovation or expansion.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.