CISPLATIN

LOE Approaching

cisplatin

NDAINJECTIONINJECTABLE
Approved
Dec 1978
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

cross-links. This interferes with normal transcription and/or DNA replication mechanisms and triggers cytotoxic processes that lead to cell death.

Pharmacologic Class:

Platinum-based Drug

Clinical Trials (5)

NCT07433673Phase 2Recruiting

Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)

Started Aug 2026
20 enrolled
Colon and Rectal Cancer
NCT07332351Phase 2Not Yet Recruiting

Neoadjuvant Intravesical Nadofaragene Firadenovec With Gemcitabine, Cisplatin and Durvalumab for the Treatment of Muscle Invasive Bladder Cancer, TRIFECTA Trial

Started Jun 2026
33 enrolled
Muscle Invasive Bladder Urothelial CarcinomaStage II Bladder Cancer AJCC v8Stage IIIA Bladder Cancer AJCC v8
NCT06855225Phase 2Not Yet Recruiting

A Phase II Study of Single Tremelimumab With Regular Interval Durvalumab Plus Gemcitabine and Cisplatin in Locally Advanced Unresectable/Metastatic Combined Hepatocellular-cholangiocarcinoma

Started Mar 2026
29 enrolled
Combined Hepatocellular and Cholangiocarcinoma
NCT07107750Phase 1Not Yet Recruiting

Emavusertib (CA-4948) in Combination With Cisplatin, Gemcitabine, and Durvalumab in Patients With Untreated Advanced or Metastatic Biliary Tract Cancer

Started Feb 2026
NCT07258979Phase 1/2Recruiting

A Study of YL201 in Combination With Toripalimab and With or Without Cisplatin in Nasopharyngeal Carcinoma.

Started Nov 2025