NDAORALTABLET1 Generic Approved
Approved
Nov 2003
Lifecycle
LOE Approaching
Competitive Pressure
45/100
Clinical Trials
20
Data completeness
6/8 — Strong
CIALIS (tadalafil) by Eli Lilly and Company is phosphodiesterase 5 inhibitors [moa]. Approved for phosphodiesterase 5 inhibitor [epc]. First approved in 2003.
Drug data last refreshed 9h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CIALIS (tadalafil) is an oral phosphodiesterase 5 (PDE5) inhibitor approved in 2003 for erectile dysfunction and other indications. It works by relaxing smooth muscle and increasing blood flow to the penis, enabling sustained erections. The drug is available as tablets and represents a mature, well-established therapeutic option in the PDE5 inhibitor class.
$6.0MPart D
LOE ApproachingApproaching loss of exclusivity with modest Part D spending; brand team focus shifting toward line extensions, cost management, and transition planning.
Mechanism of Action
Phosphodiesterase 5 Inhibitors
Pharmacologic Class:
Phosphodiesterase 5 Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Boosting Referrals to Asthma Specialists for Patients Seen at the Emergency Room for an Asthma Exacerbation
Started Jun 2026
40 enrolled
Asthma AttackAsthma ControlAsthma Exacerbations+1 more
Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke)(Stroke-CORE)
Started May 2026
12,750 enrolled
Intracerebral HaemorrhagePaediatric StrokeStroke Acute+2 more
Assess Accuracy of Primary Care Asthma and COPD Diagnosis Using Oscillometry and FeNO vs Specialist Diagnosis
Started Dec 2025
600 enrolled
AsthmaCOPD
Actual Use Trial of Tadalafil 5 mg
Started Jan 2025
2,250 enrolled
Erectile Dysfunction
Impact of Dental Desensitization Facilitated by a Child Life Specialist Distress and Cooperation
Started Aug 2024
59 enrolled
DesensitizationDental AnxietyDental Care+2 more
Worked on CIALIS at Eli Lilly and Company? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.