CHIRHOSTIM
LOE Approachinghuman secretin
NDAINTRAVENOUSFOR SOLUTIONPriority Review
Approved
Apr 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
Mechanism of Action 12.1 Mechanism of Action The primary action of ChiRhoStim is to stimulate pancreatic ductal cells to secrete pancreas fluid in large volumes that contain bicarbonate. Secretin is a hormone that is normally released from the duodenum upon exposure of the proximal intestinal lumen…