NDATOPICALSOLUTION
Approved
Jul 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CHG SCRUB (chlorhexidine gluconate) by Johnson & Johnson is clinical pharmacology periogard® (chlorhexidine gluconate oral rinse usp, 0. First approved in 1986.
Drug data last refreshed 17h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CHG SCRUB (Chlorhexidine Gluconate) is a topical antimicrobial oral rinse solution approved by FDA in 1986 that reduces oral bacteria by 54-97% through broad-spectrum activity against aerobic and anaerobic plaque organisms. The drug works via retained oral cavity deposition (~30% of dose) with slow release into oral fluids, maintaining local antimicrobial effect without significant systemic absorption or bacterial resistance development. It is used for oral hygiene and plaque control in dental and clinical settings.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30), signaling potential team consolidation and transition focus toward market defense and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY PerioGard® (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) provides antimicrobial activity during oral rinsing. The clinical significance of chlorhexidine gluconate oral rinse's antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.