NDATOPICALSOLUTION
Approved
Jul 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CHG SCRUB (chlorhexidine gluconate) by Johnson & Johnson is clinical pharmacology periogard® (chlorhexidine gluconate oral rinse usp, 0. First approved in 1986.
Drug data last refreshed 5h ago · AI intelligence enriched 8h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CHG SCRUB is a topical chlorhexidine gluconate 0.12% oral rinse solution approved by FDA in 1986 for antimicrobial oral care. It reduces bacterial plaque counts by 54-97% through broad-spectrum activity against aerobic and anaerobic organisms, with ~30% retention in the oral cavity after rinsing. The drug works through direct antimicrobial action without inducing bacterial resistance or disrupting oral microbial ecosystems.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30/100), indicating a brand in defensive consolidation mode with likely limited expansion headcount.
Mechanism of Action
CLINICAL PHARMACOLOGY PerioGard® (Chlorhexidine Gluconate Oral Rinse USP, 0.12%) provides antimicrobial activity during oral rinsing. The clinical significance of chlorhexidine gluconate oral rinse's antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.