NDAORALTABLETPriority Review
Approved
Jul 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
(chenodeoxycholic acid) is a primary bile acid, synthesized from cholesterol in the liver. In CTX, the major bile acid synthesis pathways are disrupted due to partial or total deficiency in sterol 27-hydroxylase encoded by the CYP27A1 gene. CTEXLI may act to replace deficient levels of the…