CERVIDIL

LOE Approaching

dinoprostone

NDAVAGINALINSERT, EXTENDED RELEASE
Approved
Mar 1995
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
5

Mechanism of Action

hormone. In pregnancy, dinoprostone is secreted continuously by the fetal membranes and placenta and plays an important role in the final events leading to the initiation of labor including cervical ripening. Dinoprostone stimulates the production of prostaglandin F 2α ( PGF 2α), which sensitizes…

Pharmacologic Class:

Prostaglandin Analog

Clinical Trials (5)

NCT03806231Phase 3Terminated

A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening

Started Aug 2019
8 enrolled
Induction of Labor Affected Fetus / Newborn
NCT01720394Phase 4Unknown

Efficacy of Induction of Labor on Term Using a Double Balloon Catheter Compared to Dinoprostone Vaginal-insert

Started Nov 2013
NCT01127581Phase 3Completed

Efficacy & Safety Study Comparing Misoprostol Vaginal Insert (MVI) Versus Dinoprostone Vaginal Insert (DVI) for Reducing Time to Vaginal Delivery

Started Sep 2010
1,358 enrolled
Reducing Time to Vaginal DeliveryCervical RipeningInduction of Labor
NCT01190163Phase 4Terminated

Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction

Started Jun 2010
170 enrolled
Vaginal DeliveryCesarean Section
NCT00308711Phase 3Completed

Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor

Started Apr 2006
1,308 enrolled
Cervical RipeningLabor, Induced