NDAINJECTIONINJECTABLE
Approved
Dec 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
CELESTONE (betamethasone sodium phosphate) by Merck & Co. is clinical pharmacology glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. First approved in 1974.
Drug data last refreshed 11h ago · AI intelligence enriched 5d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CELESTONE (betamethasone sodium phosphate) is a synthetic glucocorticoid administered by injection for rapid anti-inflammatory and immunosuppressive effects across multiple organ systems. The sodium phosphate ester formulation provides prompt onset of action, making it suitable for acute inflammatory conditions and systemic corticosteroid replacement therapy. Betamethasone's 16β-methyl group enhances anti-inflammatory potency while minimizing salt and water retention.
LOE Approaching
As a legacy injectable corticosteroid approaching loss of exclusivity, the brand team is likely in maintenance mode with modest headcount focused on defending generic-prone markets and managing institutional relationships.
Mechanism of Action
CLINICAL PHARMACOLOGY Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease
Started Jan 2021
349 enrolled
Dry Eye Disease
Career Relevance
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.