NDAINJECTIONINJECTABLE
Approved
Oct 1997
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
5
Data completeness
4/8 — Partial
CAVERJECT (alprostadil) by Pfizer is arteries. First approved in 1997.
Drug data last refreshed 17h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CAVERJECT (alprostadil) is a small-molecule prostaglandin E1 analog administered via intracavernosal injection to treat erectile dysfunction. It works by relaxing smooth muscle in penile arteries and expanding lacunar spaces, trapping blood via the corporal veno-occlusive mechanism to produce erection. The product targets men with ED across multiple etiologies.
LOE Approaching
As LOE approaches, the brand team is likely consolidating and shifting focus to managed decline or niche market penetration in the injection-based ED segment.
Mechanism of Action
arteries. This leads to expansion of lacunar spaces and entrapment of blood by compressing the venules against the tunica albuginea, a process referred to as the corporal veno-occlusive mechanism.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (5)
Users Study Of The Caverject Delivery System
Started Mar 2013
48 enrolled
Healthy
Caverject User Study
Started Feb 2011
48 enrolled
Erectile Dysfunction
Alprostadil in Maculopathy Study (AIMS)
Started Jul 2006
37 enrolled
Macular Degeneration
Topical Alprostadil for Female Sexual Arousal Disorder
Started Sep 2004
300 enrolled
Sexual Dysfunction, Physiological
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
Started Mar 2004
840 enrolled
Peripheral Arterial Occlusive Disease
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.