NDAINTRAVENOUSSOLUTION
Approved
Oct 2016
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20
Data completeness
4/8 — Partial
CARNEXIV (carbamazepine) by Lundbeck is mechanism of action carbamazepine has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizures. First approved in 2016.
Drug data last refreshed 10h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CARNEXIV is an intravenous formulation of carbamazepine, a small-molecule anticonvulsant approved in 2016 by Lundbeck. It reduces polysynaptic responses and blocks post-tetanic potentiation to control seizures and neuropathic pain. The drug's active metabolite, carbamazepine-10,11-epoxide, also contributes anticonvulsant activity, though its clinical significance remains under investigation.
Peak13.4 years to LOE
Product is in peak commercial phase with stable market position; commercial team size likely moderate given niche IV indication.
Mechanism of Action
Mechanism of Action Carbamazepine has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizures. It appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiation. Carbamazepine greatly reduces or abolishes pain induced…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Verducatib in the Blood
Started Sep 2026
20 enrolled
Healthy
Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazole
Started Apr 2026
28 enrolled
Healthy Participants
A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered Together
Started Mar 2026
48 enrolled
Healthy Volunteers
A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults
Started Feb 2026
54 enrolled
Healthy Volunteer
To Assess the Enzyme Inducing Effects of Carbamazepine on the PK of Mirdametinib in Healthy Participants
Started Dec 2025
36 enrolled
HealthyVolunteer
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.