CARDIZEM
LOE Approachingdiltiazem hydrochloride
NDAINJECTIONINJECTABLE
Approved
Oct 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
CLINICAL PHARMACOLOGY The therapeutic effects of diltiazem are believed to be related to its ability to inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. Mechanisms of Action Hypertension: Diltiazem produces its antihypertensive effect…