CARDENE
LOE ApproachingNDAORALCAPSULE
Approved
Dec 1988
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
CARDENE by Chiesi is concentrations. Approved for not desirable. First approved in 1988.
Drug data last refreshed 10h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
CARDENE (nicardipine) is an oral calcium channel blocker approved in 1988 for cardiovascular indications. It works by selectively inhibiting calcium ion movement into vascular smooth muscle cells, causing vasodilation with minimal negative effects on cardiac contractility. The drug is formulated as an oral capsule and is more selective for vascular smooth muscle than cardiac muscle.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30), indicating small and consolidating commercial infrastructure.
Mechanism of Action
concentrations. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. The effects of nicardipine are more selective to vascular smooth muscle than cardiac muscle. In animal…
Indications (1)
Career Relevance
Working on CARDENE offers limited career growth due to approaching LOE and zero linked job openings, indicating a shrinking team and reduced investment. Roles would focus on defending market share and managing transition to post-LOE phase rather than growth initiatives.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.